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IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. Gaggero S, et al. Among authors: thomasen fe. Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2. Sci Immunol. 2022. PMID: 36459543
Improving Martini 3 for Disordered and Multidomain Proteins.
Thomasen FE, Pesce F, Roesgaard MA, Tesei G, Lindorff-Larsen K. Thomasen FE, et al. J Chem Theory Comput. 2022 Apr 12;18(4):2033-2041. doi: 10.1021/acs.jctc.1c01042. Epub 2022 Apr 4. J Chem Theory Comput. 2022. PMID: 35377637